Adaptogenic mushrooms have become a growing topic in wellness research, particularly in studies examining how the body responds to stress and maintains internal balance. Rather than referring to a single compound or outcome, the term “adaptogenic” is used in research to describe how certain botanicals are studied for their relationship to stress signaling, resilience, and physiological adaptation. This article explores what adaptogenic mushrooms are from a scientific perspective, how researchers define adaptogenic activity, and why mushrooms such as reishi, lion’s mane, cordyceps, chaga, and turkey tail frequently appear in these discussions. By focusing on mechanisms, pathways, and research context, rather than claims or results, this guide helps readers better understand how adaptogenic mushrooms fit into broader wellness research and why they are often studied together in multi-mushroom formulations.